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Specifically, given the known acute effect of 4-HNE in activating uncoupling proteins to lower mitochondrial membrane potential, the lower abundance of ANT and UCP3 observed after 8 mo of cigarette smoke exposure might represent a late adaptation to restore proton leak when the mitochondrial membrane potential has reached a critical value that may compromise the rate of ATP synthesis

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For exclusive users of one of the three respective products, the probability of continuing to use the same product 1 year later was higher for premium cigar users (75.0 percent) than for other nonpremium cigar users (59.0 percent) but lower than for exclusive cigarette users (89.2 percent)

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